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Istradefylline 40 mg/working day increased peak degrees and AUC of CYP3A4 substrates in scientific trials. This result wasn't noticed with istradefylline 20 mg/working day. Contemplate dose reduction of sensitive CYP3A4 substrates.Indicated to further improve wakefulness in adults with too much sleepiness linked to obstructive slumber apnea (OSA)Fe

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